Networks in the Life Sciences – Genomics, Proteomics and Systems Biology
14th EMBL PhD Symposium

25th–27th October 2012

Speaker: Dr. Richard Durbin

  • Wellcome Trust Sanger Institute Human Genetics, Hinxton
  • Fellow of the Royal Society
  • EMBO member


Richard Durbin Joint head of the Human Genetics unit at the Wellcome Trust Sanger Institute, Richard Durbin is known for developing numerous methods of sequence analysis, including: GeneWise, HMMER, Pfam, Ensembl & TreeFam. He now works in human genome resequencing, focussing on the analysis of genetic variation, and is involved in the 1000 Genome Project.

Talk: Human genetic variation: from population sequencing to cellular function

There has been a dramatic decrease in DNA sequencing costs in the last few years. This has allowed direct full genome sequence studies of genetic diversity by sequencing of multiple individuals. As well as supporting evolutionary and population genetics, this allows phenotype association studies to be extended to all types of genetic variation, not just common variation assayed using genotyping chips. I will discuss some of the recent results from the 1000 Genomes Project. I will also discuss various studies correlating genetic variation with variation between individuals’ cellular traits such as microRNA expression, and protein binding to DNA measured by ChIP-seq.